Continuous Chromatography

Industrial Chromatographic Separation Technology Principle
The SepTor chromatographic separation technology is basing on different distributing coefficient of different substances in the system formed by static & flowing phases, the separation purpose is realized by different retention time in elution process of flowing phase. The traditional chromatographic technology is carried out in the static chromatographic resin tower, the feed goes into the tower firstly, then it’s repeatedly eluted by eluent, different product components come out from the same outlet in different time, but it takes time and effort in this process.

After long time practice & experience, we improved the design and made the continuously flowable system from the static resin tower, the separation is realized by the correspondingly different moving speed between substance and static phase. It’s similar to the principle of match between turtles and rabbits. We look the belt as static phase, the turtles and rabbits as two different components with slow & fast speed, the driving force is put into the static phase with same direction of elution, making the moving speed of belt is between turtles and rabbits' speed, the rabbits running faster are got in front end, but the turtles running slower are brought to back end by belt.

Continuous Ion Exchange Technology Principle
Ion exchange technology is a process based on the exchange between resin functional groups and specific ions, which is a reversible and equivalent reaction. Active zone is divided into several small units, when one unit is saturated, it will be shifted to the next process such as washing and regeneration. Then the treated resin again returns to the active zone for recycling, which will improve the resin utilization greatly.

In order to realize an automatic and efficient operation, several resin vessels are placed on a rotating turntable to realize automatic switching of different functions & vessels. The vessels are divided into the following functional units such as exchange, washing, regeneration, and rinsing. When one vessel turns to the specific unit, the corresponding process will be implemented.

Compared to traditional batch chromatography this process leads to higher yields of purified substances while consuming less eluent and packing material.