Bio-Oligo Pro 400 Nucleic Acid Synthesizer
The Oligonucleotide Synthesizer features an explosion-proof design and complies fully with GMP production standards. The compact architecture and minimal footprint render it exceptionally suitable for pilot-scale operations, while its robust capacity ensures reliable and consistent batch production at the hundred-gram scale.
Technical Features of Bio-Oligo Pro 400 Nucleic Acid Gene Synthesizer Machine
01.
Biocompatibility
Incorporates a stacked piping configuration with minimal dead volume, designed to withstand conventional organic solvents such as acetonitrile and toluene, as well as dichloroacetic acid (3–10%) and other reactive reagents.
02.
Precision Flow Accuracy
Constructed from high-grade stainless steel, the system incorporates three pump heads with integrated online mixing capability, delivering exceptional flow precision. Each pump head is equipped with an automated self-cleaning function for sustained performance.
03.
Multi user management
Advanced software architecture supports multi-user access with hierarchical permission settings, enabling secure management, traceability, and operational accountability.
04.
Flexible Method Programming
An intuitive interface allows full customization of synthesis parameters and method editing, combining simplicity of operation with a refined human–machine interaction experience.
05.
Comprehensive Automation
The complete synthesis cycle is software-controlled, with continuous monitoring and recording of pressure, conductivity, and UV detection values to ensure rigorous process oversight.
06.
Individually customized
Tailored Customization Options extend to software configurations, synthesis columns, and reagent bottle specifications, providing adaptability to diverse research and production requirements.
07.
Regulatory Compliance
Software is designed in accordance with international regulatory frameworks, including 21 CFR Part 11, ensuring adherence to industry standards and facilitating validation for clinical and industrial applications.
Bio-Oligo Pro 400 Nucleic Acid/Gene Synthesizer Machine Specification
Infusion pump
Plunger pump, stainless steel material
Synthesis scale
4mmol-48mmol
Flow rate range
0~400ml/min
Number of individual entrances
11 (standard)
Operating pressure
15bar (218psi)
Maximum operating pressure
1
UV detector
4-channel UV detector, Wavelength range 200-800nm, accuracy ±1nm
Protective gas pressures
Nitrogen/Argon, 0.1~0.25bar, inlet tube size 6mm
Conductivity Detectors
Detection range 1uS/cm~300mS/cm
Exterior Dimensions
1430x1050x1940mm (L x W x H)
Power supply pressure
220V±5%AC
Power (output)
2000W
Pipeline material
PTFE tube
Frequently Asked Questions
The Bio-Oligo Pro 400 oligonucleotide synthesizer is designed for production on a pilot to 100-gram scale. Its GMP-compliant, explosion-proof design guarantees dependable, safe, and consistent synthesis for industrial and pharmaceutical production settings.
Triple stainless-steel pump heads with online mixing and automated self-cleaning are features of this oligo synthesis machine. These systems ensure consistent synthesis results in each batch by providing accurate flow control and stable operation.
The system is suitable for specific solid-phase peptide synthesis or nucleic acid-based applications since it allows for a great deal of customisation, including software configurations, synthesis column diameters, and reagent bottle options.
Full automated process control is provided by the synthesizer, which also continuously monitors variables including conductivity, pressure, and UV detection. This guarantees correctness and smooth operation during each synthesis cycle.
Of course. Its hardware and software adhere to 21 CFR Part 11 requirements and GMP standards, guaranteeing regulatory compliance, validation, and traceability for both commercial manufacturing and clinical research.
Contact Intech Analytical Instruments
Office Address
Plot no, 680, Rd Number 15, Vasanth Nagar, Kukatpally, Hyderabad, Telangana 500085
Lab Address
Plot No: 13, Sy No: 62/1/A,
Kakateeya Nagar, Bahadurpally, Dundigal,
Gandimaisamma, Medchal - 500043