Oligonucleotide Synthesizer
Oligonucleotide Synthesis is the process of chemically creating short DNA or RNA sequences in the laboratory. It involves the step-by-step assembly of nucleotides to form the desired sequence. Once the synthesis by the Oligo Synthesizer Machine is complete, purification methods are employed to isolate and obtain pure Oligonucleotides for various applications, such as research, diagnostics, and therapeutic development.
Product Overview
From basic development to commercial scale-up, Intech-Hanbon provides comprehensive Oligonucleotide Synthesis solutions that support each crucial step of API production. Our portfolio ensures that both manufacturers and researchers may proceed through the full process with ease by combining precision, flexibility, and compliance.
- Synthesis: Equipment with various scales that facilitate both industrial production and laboratory optimization.
- Purification: Consistent and pure systems that work with ion-exchange and reversed-phase chromatography techniques
- Scalable salt exchange and concentration solutions that preserve stability and effectiveness throughout production are provided by ultrafiltration.
When combined, these technologies offer a cohesive route that supports the highest dependability and regulatory compliance criteria while facilitating seamless transitions from research to large-scale manufacturing.
Foundation of Oligonucleotide Synthesis by Automated Systems
Modern Oligonucleotide Synthesis mostly uses automated synthesizer platforms that combine phosphoramidite monomers and solid-phase chemistry. A nucleobase, deoxyribose, a 2-cyanoethyl group, a 5′-DMT protecting group, and a 3′-terminal diisopropylamine moiety are all included in these monomers during DNA assembly. However, to avoid cross-reactivity with the 5′-hydroxyl during chain elongation, RNA Synthesis requires selective protection of the 2′-hydroxyl, which is typically provided by TBDMS groups. In the past, the synthesis surface was supplied by controlled-pore glass (CPG) carriers; however, their loading capabilities were restricted to 70–80 μmol/g. High-capacity matrices (250–350 μmol/g) are now available thanks to advancements in carrier technology, which allow for increased yields and scalability in both industrial and research applications.
Types of Oligo Synthesizer Machine
Bio-Oligo Laboratory Nucleic Acid Synthesis Instrument
Bio-Oligo Pro 400 Nucleic Acid Synthesizer
Bio Oligo Pro Series Production Grade Nucleic Acids
Oligonucleotide Synthesis Column
Contact Intech Analytical Instruments
Office Address
Plot no, 680, Rd Number 15, Vasanth Nagar, Kukatpally, Hyderabad, Telangana 500085
Lab Address
Plot No: 13, Sy No: 62/1/A,
Kakateeya Nagar, Bahadurpally, Dundigal,
Gandimaisamma, Medchal - 500043